Sayani Bhattacharjee, who manages the field application scientist team in Bruker Spatial Biology’s East region. This presentation outlines the company’s portfolio of spatial multiomic technologies. She began by discussing Bruker's vision, which focused on understanding biology and curing diseases through high plex discovery approaches. The journey with spatial biology started in 2019 with the launch of the GeoMx platform, initially featuring an 84 plex panel. Over the years, the plex increased, culminating in the launch of the whole transcriptome platform in 2021 and the CosMx platform in 2022, which allowed for single-cell spatial data analysis.
Bhattacharjee highlighted the capabilities of GeoMx and CosMx, noting that GeoMx could profile different cell populations and analyse over 570 proteins, while CosMx provided single-cell resolution for transcript and protein data. She used a case study involving lymph node tissue to illustrate how these technologies could answer research questions about spatial domains and cell types. The GeoMx data revealed three distinct zones within germinal centres, each with unique pathway enrichments. The CosMx data further identified specific cell interactions driving the observed biology.
The presentation also covered the integration of GeoMx and CosMx in research, with GeoMx providing insights into what happened and CosMx explaining who did it and how. Bhattacharjee discussed the extensive data generated from these platforms, including 1.4 million single cells and 27 different cell types. She emphasised the importance of data analysis and the role of the AtoMx spatial informatics platform in visualising and analysing the data.
Bhattacharjee concluded by discussing the future of spatial biology research, including the launch of the CosMx Whole Transcriptome panel and its potential for scientific discovery. She provided examples of novel findings, such as olfactory receptor signals in colon tissue used for IBD research. The presentation underscored Bruker's commitment to pushing the boundaries of spatial biology and supporting the research community.
