Ariadne.AI was founded in 2014 and specialises in developing software and services for processing microscopy data. Initially focused on three-dimensional electron microscopy, the company expanded to support various microscopy techniques, addressing the challenges posed by large data volumes.
In this presentation Fabian Svara highlighted the company's global clientele, predominantly in Western Europe and North America, and their significant presence in high-impact journals. He detailed the range of services offered by Ariadne.AI, including model engineering, software engineering, and model-as-a-service. The latter includes pre-built models like 3dEMtrace for electron microscopy and LMtrace for neuron tracing.
A key focus of the presentation was the spatial software, a browser-based tool for analysing multiplexed images. Svara highlighted its scalability, ease of use, and device agnosticism. The software supports various data formats and enables collaborative features, such as sharing links to specific data locations. He explained the importance of browser-based software for handling large image datasets, which require high-performance computing environments.
Svara then described the workflow enabled by the spatial software, from data ingestion and registration to masking, cell segmentation, and marker mapping. He highlighted the software's ability to perform elastic registration, correct image deformations, and provide pre-trained models for various tasks. The software's applications include complex cellular morphologies, multi-omic registration, and tissue annotation, particularly in neuro and immune applications.
The presentation also covered a case study by Bahareh Ajami at OHSU, who used the spatial software to analyse postmortem human brain data. She segmented blood vessels, cells, and amyloid beta aggregates, identifying subtypes of microglia associated with Alzheimer's disease. The software enabled her to perform clustering based on morphology and protein expression, revealing significant differences between Alzheimer's and control cohorts.
